Professor of Biochemistry and Molecular Biology Ph.D. (1981) University of Washington Grant Support - "Antisense RNAs control retrotransposon movement", NIH Selected Publications Selected Publications: Purzycka, K.J., M. Legiewicz, E. Matsuda, L.D. Eizentstat, S. Lusvarghi, A. Saha, S.F. Le Grice and D.J. Garfinkel. Exploring Ty1 retrotransposon RNA structure within virus-like paticles. 2013. Nucleic Acids Res. 41(1): 463-73. Checkley, M.A., J.A. Mitchell, L.D. Eizenstat, S.J. Lockett, and D.J Garfinkel. 2012. Ty1 Gag mediates the accumulation and nuclear export of Ty1 mRNA. 2013. Traffic 14(1): 57-69. Checkley, M. A., K. Nagashima, S. Lockett, and D. J. Garfinkel. 2010. P-bodies are required for Ty1 retrotransposition during assembly of virus-like particles. Mol Cell Biol. 30:382-398. Dakshinamurthy A., K.M. Nyswaner, P.J. Farabaugh, and D.J. Garfinkel. 2010. BUD22 affects Ty1 retrotransposition and ribosome biogenesis in Saccharomyces cerevisiae. Genetics 185:1193-1205. Matsuda, E. and D. J. Garfinkel. 2009. Posttranslational interference of Ty1 retrotransposition by antisense RNAs. Proc Natl Acad Sci USA. 106:15657-15662. Moore, S. P. and D. J. Garfinkel. 2009. Functional analysis of N-terminal residues of Ty1 integrase. J. Virol. 83:9502-9511. Nyswaner, K.M., M.A. Checkley, M. Yi, R.M. Stephens, and D.J. Garfinkel. 2008. Chromatin associated genes protect the yeast genome from Ty1 insertional mutagenesis. Genetics 178:197-214. Curcio, M.J., A.E. Kenny, S. Moore, D.J. Garfinkel, M. Weintraub, E.R. Gamache and D.T. Scholes. 2007. S-phase checkpoint pathways stimulate the mobility of the retrovirus-like transposon Ty1. Mol Cell Biol. 27:8874-8885. Garfinkel, D.J., Stefanisko K.M., Nyswaner K.M., Moore S.P., Oh J., and Hughes S.H. 2006. Retrotransposon suicide: formation of Ty1 circles and autointegration via a central DNA flap. J Virol. 80:11920-11934. Asefa, B., J.M. Dermott, P. Kaldis, K.M. Stefanisko, D.J. Garfinkel, and J.R. Keller. 2006. p205, A potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. FEBS Letters 580:1205-1214. Nissley, D.V., E. Halvas, N. Hoppman, D.J. Garfinkel, J. Mellors, and J.N. Strathern. 2005. Sensitive phenotypic detection of minor drug resistant HIV-1 reverse transcriptase variants. J. Clin. Micro. 43:5696-5704. Garfinkel, D.J. 2005. Genome evolution mediated by Ty elements in Saccharomyces. Cytogenetics Genome Res. 110:63-69 Garfinkel, D.J., K.M. Nyswaner, K.M. Stefanisko, C. Chang, and S.P. Moore. 2005. Ty1 copy number dynamics in Saccharomyces. Genetics 169:1845-1857. Moore, S.P., G. Liti, K.M. Stefanisko, K.M. Nyswaner, C. Chang, E.J. Louis, and D.J. Garfinkel. 2004. Analysis of a Ty1-less variant of Saccharomyces paradoxus: the gain and loss of Ty1 elements. Yeast 21:649-660. Garfinkel, D.J. 2004. When toothpicks mattered: using microbial genetics and transposon tagging to map the T-DNA. In The Agrobacterium Anthology (E.W. Nester, M.P. Gordon, and A. Kerr eds.), American Phytopathological Society Press, St. Paul, MN. pp. 116-129. Sundararajan, A., B.S. Lee, and D.J. Garfinkel. 2003. The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae. Genetics 163:55-67. Martin, S.L. and D.J. Garfinkel. 2003. Survival strategies for transposons and genomes. Genome Biol 4:313-315. Garfinkel, D.J., K.M. Nyswaner, J. Wang, and J.-Y. Cho. 2003. Post-transcriptional cosuppression of Ty1 retrotransposition. Genetics 165:83-99. Giaever, G., et al. 2002. Functional profiling of the S. cerevisiae genome. Nature 418:387-391. Garfinkel, D.J. and A.M. Bailis. 2002. Nucleotide excision repair, genome stability, and human disease: New insight from model organisms. J Biomed Biotechnol 2:55-60. Li, A., R.C. Sowder II, L.E. Henderson, S.P. Moore, D.J. Garfinkel, and R.J. Fisher. 2001. Chemical cleavage at aspartyl residues for protein identification. Anal Chem 73:5395-5402. Rattray, A.L., B.K. Shafer, and D.J. Garfinkel. 2000. The Saccharomyces cerevisiae DNA recombination and repair functions of the RAD52 epistasis group inhibit Ty1 transposition. Genetics 154:543-556. Moore, S.P. and D.J. Garfinkel. 2000. Correct integration of model substrates by Ty1 inegrase. J Virol 74:11522-1130. Lee, BS, L. Bi, D.J. Garfinkel, and A.M. Bailis. 2000. Nucleotide excision Repair/TFIIH helicases Rad3 and Ssl2 inhibit short-sequence recombination and Ty1 retrotransposition by similar mechanisms. Mol Cell Biol 20:2436-2445. Feng, Y., S.P. Moore, D.J. Garfinkel, and A. Rein. 2000. The genomic RNA in Ty1 virus-like particles is dimeric. J Virol 74:10819-10821.
