Professor Eminent Scholar Director PhD (1993) University of Wisconsin-Madison Grant Support - Southeast Center for Integrated Metabolomics (NIH U24DK097209), 09/01/13-08/31/18. SECIM is one of 6 NIH centers for metabolomics. Prof. Edison was the founding PI and Director at the University of Florida, and he now in PI of a UGA subcontract for NMR metabolomics. Research Interests - The Edison lab uses metabolomics and natural products chemistry to understand the chemical basis of behavior. Our primary organism for this work is Caenorhabditis elegans, a small, free-living nematode. C. elegans has been one of the best studied animals in science, with an extensive genetics, anatomy, cell, and developmental biology knowledge-base. Less is known about the role of small molecules in its development and behavior, and our studies in metabolomics can leverage the extensive understanding of this worm. We also are very interested in other nematodes, including parasitic species. Prof. Edison got his start in nematodes as a postdoc working on Ascaris suum, a large intestinal pig parasite that is very similar to a related species, Ascaris lumbricoides, which infects about 1 billion people world-wide. Selected Publications Selected Publications: “Metabolomics and Natural Products Strategies to Study Chemical Ecology in Nematodes” Arthur S. Edison*, Chaevien Clendinen, Ramadan Ajredini, Chris Beecher, Francesca Ponce, and Gregory Stupp. In Press, Invited contribution to the Journal of Integrative and Comparative Biology (2015)“An Overview of Methods for Improved Compound Identification in Metabolomics and Natural Products Using 13C.” Arthur S. Edison*, Chaevien S. Clendinen, Gregory S. Stupp+, Ramadan Ajredini, and Chris Beecher. In Press, Invited contribution to Frontiers in Plant Science (2015).Chaevien S. Clendinen, Christian Pasquel, Ramadan Ajredini, Arthur S. Edison* “13C NMR Metabolomics: INADEQUATE Network Analysis”, Anal. Chem. 87(11), 5698-5706 (2015).Menger, R. F. ‡, Clendinen, C.‡, Searcy, L. A., Edison, A. S., & Yost, R. A.*, “MALDI Mass Spectrometric Imaging of the Nematode Caenorhabditis elegans” Current Metabolomics 3, 130-137 (2015).Frelin, O., Huang, L., Hasnain, G., Jeffryes, J. G., Ziemak, M. J., Rocca, J. R., Wang, B., Rice, J., Roje, S., Yurgel, S. N., Gregory, J. F., Edison, A. S., Henry, C. S., de Crecy-Lagard, V., and Hanson, A. D.* (2015) A directed-overflow and damage-control N-glycosidase in riboflavin biosynthesis., Biochem J 466, 137-145.Clendinen, C. S., Lee-McMullen, B., Williams, C. M., Stupp, G. S., Vandenborne, K., Hahn, D. A., Walter, G. A., and Edison, A. S.* (2014) “¹³C NMR metabolomics: applications at natural abundance”, Analytical Chemistry 86, 9242-9250.Williams, C. M., Watanabe, M., Guarracino, M. R., Ferraro, M. B., Edison, A. S., Morgan, T. J., Boroujerdi, A. F., and Hahn, D. A.* (2014) “Cold adaptation shapes the robustness of metabolic networks in Drosophila melanogaster”, Evolution 68, 3505-3523.Stupp, G.S., Clendinen, C., Ajredini, R., Szewc, M.A., Garrett, T., Menger, R.F., Yost, R.A., Beecher, C.* & Edison, A.S.* “Isotopic Ratio Outlier Analysis Global Metabolomics of Caenorhabditis elegans” Anal. Chem. 85, 11858-65 (2013).Ramaswamy, V., Hooker, J.W., Withers, R.S., Nast, R.E., Brey, W.W*., Edison, A.S.* “Development of a 13C-Optimized 1.5-mm High Temperature Superconducting NMR Probe” J. Magn. Reson. 235C, 58–65. (2013).Stupp, G. S., Reuss, von, S. H., Izrayelit, Y., Ajredini, R., Schroeder, F. C.*, and Edison, A. S.* (2013) “Chemical detoxification of small molecules by Caenorhabditis elegans” ACS chemical biology 8, 309–313. Featured in C&E News, Science and Technology Concentrates, Dec 3, 2012.Choe, A.&, Chuman, T.&, von Reuss, S.H.&, Dossey, A.T.&, Yim, J., Ajredini, R., Kolawa, A.A., Kaplan, F., Alborn, H.T., Teal, P.E., Schroeder, F.C., Sternberg, P.W., & Edison, A.S.* “Gender-Specific Mating Pheromones in the Nematode Panagrellus redivivus”, PNAS 109, 20949-20954 (2012).Fatma Kaplan; Hans T Alborn; Stephan H von Reuss; Ramadan Ajredini; Jared G Ali; Faruk Akyazi; Lukasz L Stelinski; Arthur S Edison; Frank C Schroeder; Peter E Teal*, "Interspecific nematode signals regulate dispersal behavior", PLoS One, 7(6), e38735, doi:10.1371/journal.pone.0038735 (2012).Srinivasan, J., von Reuss, S.H., Bose, N., Mahanti, P., Ho, M.C., O’Doherty, O.G., Edison, A.S., Sternberg, P.W.* & Schroeder, F.C.*, “A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans”, PLoS Biol 10(1): e1001237. doi:10.1371/journal.pbio.1001237 (2012).Robinette, S.L., Ajredini, R., Rasheed, H., Zeinomar, A., Schroeder F.C., Dossey, A.T., & Edison, A.S.*, “Hierarchical Alignment and Full Resolution Pattern Recognition of 2D NMR Spectra: Application to Nematode Chemical Ecology.”, Analytical Chemistry 83 (5), 1649–1657 (2011). PMID: 21314130Kaplan, F., Srinivasan, J., Mahanti, P., Ajredini, R., Durak, O., Nimalendran, R., Sternberg, P.W., Teal, P.E.A, Schroeder, F.C., Edison, A.S., and Alborn, H.T.*, “Ascaroside expression in Caenorhabditis elegans is strongly dependent on diet and developmental stage”, PLoS One 6(3):e17804, (2011). PMID: 21423575Waller, J.C., Alvarez, S., Naponelli, V., Lara-Nuñez, A., Blaby, I.K., Da Silva, V., Ziemak, M.J., Vickers, T.J., Beverley, S.M., Edison, A.S., Rocca, J.R., Gregory III, J.F., de Crécy-Lagard, V., & Hanson, A.D.* “A Newly Discovered Role for Tetrahydrofolates in the Metabolismof Iron-Sulfur Clusters in All Domains of Life”, PNAS 107, 10412-72010 (2010). PMID: 20489182Kaplan, F., Badri, D. V., Zachariah, C., Ajredini, R., Sandoval, F. J., Roje, S., Levine, L. H., Zhang, F., Robinette, S. L., Alborn, H. T., Zhao, W., Stadler, M., Nimalendran, R., Dossey, A. T., Brüschweiler, R. A., Vivanco, J. M., Edison, A. S.* “Bacterial Attraction and Quorum Sensing Inhibition in Caenorhabditis elegans Exudates”, Journal of Chemical Ecology 35(8):878-92 (2009). PMID: 19649780Dossey, A. T.*, Gottardo, M., Whitaker, J., Roush, W. R., & Edison, A. S. “AlkylDimethylpyrazines in the Defensive Spray of Phyllium westwoodii: A First for Order Phasmatodea”, Journal of Chemical Ecology 35(8):861-70 (2009). PMID: 19685263. This is a cover article.Dalisay, D. S., Rogers, E. W., Edison, A. S., Molinski, T. F.* Structure Elucidation at the Nanomole-Scale. Trisoxazole macrolides and Thiazole-containing cyclic peptides from the Nudibranch Hexabranchus sanguineus, Journal of Natural Products 72, 732-8 (2009). PMID: 19254038Srinivasan, J., Kaplan, F., Ajredini, R., Zachariah, C., Alborn, H., Teal, P., Edison, A. S.*, Paul W. Sternberg, P. W.*, & Schroeder, F. C.* “A synergistic blend of small molecules differentially regulates both mating behavior and population density in Caenorhabditis elegans.”, Nature 454, 1115-1118 (2008). PMID: 18650807 Featured in Nature Chemical Biology and SpectroscopyNOW.comDossey, A. T., Walse, S. S., & Edison, A. S.* “Developmental and Geographical Variation in the Chemical Defense of the Walkingstick Insect Anisomorpha buprestoides” Journal of Chemical Ecology, 34(5), 584-590 (2008). PMID: 18401661Zhang, F.; Dossey, A. T.; Zachariah, C.; Edison, A. S., & Brüschweiler, R.* “Strategy for Automated Analysis of Dynamic Metabolic Mixtures by NMR - Application to an Insect Venom”, Anal Chem. 79, 7748-52. (2007). PMID: 17822309Dossey, A. T.; Walse, S. S.; Conle, O. V.; Edison, A. S. * “Parectadial: A Novel Monoterpenoid from the Defensive Spray of Parectatosoma mocquerysi”, J Nat Prod. 70, 1335-8 (2007). PMID: 17661519 JNP 2007 Hot Article, C&E News, Beal AwardDossey, A. T., Walse, S. S., Rocca, J. R., & Edison, A. S.* “Single Insect NMR: A New Tool to Probe Chemical Biodiversity” ACS Chemical Biology, 1 (8), 511–514 (2006). PMID: 17168538 This was a cover article and was also featured in C&E News in “News of the Week”, Sept. 25, 2006, page 15Brey, W., Edison, A.S.*, Nast, R.E., Rocca, J., Saha, S., & Withers, R. “Design, Construction, and Validation of a 1-mm Triple-Resonance High-Temperature-Superconducting Probe for NMR” Journal of Magnetic Resonance 179, 290-3 (2006). PMID: 16423543 This was a cover article.
